DR3 (Death Receptor 3/Apo3) Polyclonal Antibody

DR3 (Death Receptor 3/Apo3) Polyclonal Antibodyis available at Gentaur for Next week Delivery.

Description: Apoptosis can be induced by certain cytokines including TNF and Fas in the TNF superfamily through interaction with their death domain (DD) containing receptors, TNFR1 and Fas. A member of the TNF receptor family was recently identified and designated DR3 (also called Wal-1, Apo3, TRAMP and LARD). The ligand for this novel death receptor has been defined as TWEAK (also termed Apo3L). Like TNFR1, overexpression of DR3 triggers apoptosis and NF-kB activation. Activation of DR3 results in recruitment of TRADD (a DD containing adapter molecule). TRADD associates with FADD, TRAF2, and RIP to activate the signaling complex for NF-kB activation. DR3 activates apoptosis through TRADD, FADD, and caspase-8. DR3 is highly expressed in the tissues enriched in lymphocytes including peripheral blood leucocytes (PBL), thymus and spleen.

Immunogen Sequence:Synthetic peptide corresponding to residues surrounding amino acids 400 of human DR3.

Target Alternative Name:Apo 3, LARD, TNFRSF12, TRAMP, TNFRSF25, WSL1

Species Reactivities:Human, Mouse, Rat

Tag Line:Polyclonal Antibody to detect DR3 in Human, Mouse, Rat samples

Formulation:100 µg (0.5 mg/ml) antigen affinity-purified rabbit anti-DR3/Apo3 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.

Purification: Affinity purified rabbit IgG

Application:Western blot

Positive Control:N/A

Application And Usages:Western blot: 1-4 µg

Handling:The antibody solution should be gently mixed before use.