BRD3-BD2 Antibody

BRD3-BD2 Antibodyis available at Gentaur for Next week Delivery.

Description: The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. BRD3 binds hyper-acetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. It regulates transcription by promoting the binding of the transcription factor GATA1 to its targets and transcription of the CCND1 gene. A chromosomal aberration involving BRD3 was found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people.

Immunogen Sequence:Recombinant human BRD3-BD2 protein (Cat # 7257)

Target Alternative Name:KIAA0043, RING3L

Species Reactivities:Human

Tag Line:Polyclonal Antibody to detect BRD3-BD2 in human samples

Formulation:0.5 mg/ml of affinity purified antibody in PBS pH 7.2, with 30% glycerol, 0.5% BSA, 0.5 mM EDTA, and 0.03% Proclin

Purification: Affinity Purified Antibody

Application:Western blot

Positive Control:Western Blot: Recombinant protein

Application And Usages:Western blot: 1-4 µg/ml.

Handling:The antibody solution should be gently mixed before use.