BMPR2 Antibody (NT)

BMPR2 Antibody (NT)is available at Gentaur for Next week Delivery.

Description: BMPR2 is a type II serine/threonine receptor kinase that binds to an array of secreted bone morphogenetic proteins (BMPs). BMPs belong to the superfamily of TGF-β ligands that modulate gastrulation, neurogenesis, chondrogenesis, interdigital cell death, and bone morphogenesis. In contrast to the TGF-β type II receptor, BMPR2 contains an extended carboxyl-terminal region that interacts with multiple signaling molecules to modulate the responsiveness of target genes to BMPs. BMP signaling requires oligomerization of both type I and type II receptors to elicit a functional response of target genes. BMP binding to type I and II receptors induces Smad1/5/8 phosphorylation which is required for the activation of target genes. In vitro and in vivo evidence suggests that defects in BMPR2 may contribute to pulmonary hypertension, inflammation, and endothelial injury.

Immunogen Sequence:This BMPR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-59 amino acids from the N-terminal region of human BMPR2.

Target Alternative Name:BMPR2; PPH1; Bone morphogenetic protein receptor type-2; Bone morphogenetic protein receptor type II

Species Reactivities:Human, Mouse.

Tag Line:Polyclonal Antibody to detect BMPR2 in human and mouse samples.

Formulation:In PBS with 0.09% (W/V) sodium azide.

Purification: Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Application:Western blot, IHC, FACS.

Positive Control:Western blot: mouse heart tissue lysate, IHC: human hepatocarcinoma and kidney tissues, FACS: HepG2 cells.

Application And Usages:WB: 1:1000, IHC: 1:10 – 1:50, FC: 1:10 – 1:50.

Handling:The antibody solution should be gently mixed before use.