Bad monoclonal Antibody

Bad monoclonal Antibodyis available at Gentaur for Next week Delivery.

Description: Bad is a member of the Bcl-2 family proteins. Within the Bcl-2 homology domains 1 and 2 (BH1 and BH2), Bad shows significant homology to Bcl-2 and Bcl-x. Bcl-2 is known to block several apoptosis signals and is considered to be a central downstream cell death repressor. Bcl-XL represses apoptosis, but its short form, Bcl-XS, promotes cell death. Bax is known to homodimerize as well as heterodimerize with Bcl-2. An excess concentration of Bax opposes the ability of Bcl-2 to repress cell death. Bad can selectively dimerize with Bcl-xL and Bcl-2, but not with Bax, Bcl-xS, Mcl-1, A1, or itself. In mammalian cells, Bad binds more strongly to Bcl-xL than Bcl-2, which may explain why Bad reverse the death repressor activity of Bcl-xL, but not that of Bcl-2. The formation of the Bad-Bcl-xL heterodimer displaces Bax and restores favorable conditions for apoptosis.

Immunogen Sequence:Full length human Bad

Target Alternative Name:BAD antibody,BAD human antibody,BBC 2 antibody,BBC2 antibody,BBC6 antibody,Bcl 2 Antagonist of Cell Death antibody,Bcl 2 Binding Component 6 antibody,BCL X / BCL 2 Binding Protein antibody,BCL X Binding Protein antibody,Bcl XL/Bcl 2 Associated Death Promoter antibody,Bcl-2-binding component 6 antibody,Bcl-2-like protein 8 antibody,Bcl-XL/Bcl-2-associated death promoter antibody,Bcl2 antagonist of cell death antibody,BCL2 antagonist of cell death protein antibody,BCL2 associated agonist of cell death antibody,Bcl2 Associated Death Promoter antibody,BCL2 binding component 6 antibody,BCL2 binding protein antibody,Bcl2 Like 8 Protein antibody,Bcl2-L-8 antibody,BCL2L8 antibody,BclXL antibody,Proapoptotic BH3 Only Protein antibody.

Species Reactivities:Human, Mouse, Rat

Tag Line:Polyclonal Antibody to detect Bad in Human, Mouse, Rat samples

Formulation:100 µg (200 µg/ml) in PBS containing 1 mg/ml BSA and 1.5 mM sodium azide and 50% glycerol.

Purification: Affinity purified rabbit IgG

Application:Western blot

Positive Control:Western Blot

Application And Usages:Western blot: 1-4 µg

Handling:The antibody solution should be gently mixed before use.