BACE2/Asp1 Antibody

BACE2/Asp1 Antibodyis available at Gentaur for Next week Delivery.

Description: Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-soμght beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1. BACE2 also cleaves APP at beta-site and at a different site within Abeta. BACE2 locates on chromosome 21q22.3, the so-called 'Down critical region', sμggesting that BACE2 and Abeta may also contribute to the pathogenesis of Down syndrome.

Immunogen Sequence:A synthetic peptide corresponding to the amino acids 44 to 59 of human BACE2.

Target Alternative Name:BACE2, Asp1

Species Reactivities:Human, mouse, rat

Tag Line:Polyclonal antibody to detect BACE2/Asp1 in human samples.

Formulation:100 μg (0.5 mg/ml) affinity purified rabbit anti-BACE2 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.

Purification: Affinity chromatography purified via peptide column.

Application:Western blot

Positive Control:/

Application And Usages:Western Blot: 1-4 μg/ml. However, the optimal conditions should be determined individually.

Handling:The antibody solution should be gently mixed before use.