APG12/ATG12 Antibody

APG12/ATG12 Antibodyis available at Gentaur for Next week Delivery.

Description: Autophagy, the process of bulk degradation of cellular proteins throμgh an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) throμgh phosphorylation of autophagy protein APG1. ATG12, another member of the autophagy protein family, forms a conjμgate with ATG5; this conjμgate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy. This conjμgate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells. ATG12 has also been shown to interact with ATG10 in human embryonic kidney cells in the presence of ATG7. At least two isoforms of ATG12 are known to exist.

Immunogen Sequence:Synthetic peptide surrounding amino acid 21 of mouse APG12

Target Alternative Name:APG12 , APG12L , ATG12 , HAPG12

Species Reactivities:Human, mouse, rat

Tag Line:/

Formulation:0.5 mg/ml affinity purified rabbit anti-APG12 in PBS containing 30% glycerol, 0.5 mg/ml BSA and 0.01% thimerosal.

Purification: Affinity purified

Application:Western blot

Positive Control:/

Application And Usages:Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually.

Handling:The antibody solution should be gently mixed before use.