APG10/ATG10 Antibody

APG10/ATG10 Antibodyis available at Gentaur for Next week Delivery.

Description: Autophagy, the process of bulk degradation of cellular proteins throμgh an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) throμgh phosphorylation of autophagy protein APG1. Another member of the autophagy protein family is APG10 (Also called ATG10, APG10L), an E2-like enzyme involved in two ubiquitin-like modifications essential for autophagosome formation: ATG12-ATG5 conjμgation and the modification of a soluble form of MAP-LC3, a homolog of yeast Apg8, to a membrane-bound form. ATG10 has also been shown to interact with ATG12 in human embryonic kidney cells in the presence of ATG7. Multiple isoforms of ATG10 are known to exist.

Immunogen Sequence:Synthetic peptide, near the carboxyl terminus of human APG10

Target Alternative Name:APG10 , APG10L, ATG10 , DKFZP586I0418 , FLJ13954 , pp12616

Species Reactivities:Human, mouse, rat

Tag Line:/

Formulation:0.5 mg/ml affinity purified rabbit anti-APG10 in PBS containing 30% glycerol, 0.5 mg/ml BSA and 0.01% thimerosal.

Purification: Affinity purified

Application:Western blot

Positive Control:/

Application And Usages:Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Other applications have not been determined.

Handling:The antibody solution should be gently mixed before use.