Anti-Osteopontin (Clone 14C08)

Anti-Osteopontin (Clone 14C08)is available at Gentaur for Next week Delivery.

Description: Human Osteopontin (OPN) is a negatively charged hydrophilic protein of 314 amino acids and is subject to significant post translational modifications. OPN is cleaved by members of the matrix metalloproteinase family (MMP) which results in the generation of N-terminal and C-terminal OPN fragments. The matricellular protein osteopontin binds to cell surface receptors and is secreted into many body fluids including milk, blood and urine, depending on the organ of origin. This makes osteopontin an ideal candidate for being a biomarker as the secreted form is easily obtained in throwaway fluids, and mimics the cellular environment from which it is released. Osteopontin is important in immune responses and inflammation as well as bone generation and remodeling. In autistic children, serum levels of osteopontin are correlated to the severity of disease, probably due to a brain inflammation pattern in these children. In aortic valve sclerosis and stenosis, increased levels of secreted osteopontin are also noted. Osteopontin has also been sμggested as a cancer biomarker, since it is associated with tumor formation, progression and metastasis. In bone and tooth formation osteopontin is known to be a negative regulator of parathyroid hormone-related protein receptor, which induces osteogenesis. Without appropriate levels of osteopontin, bone growth continues unregulated, and leads to specific bone cancers. In short, osteopontin is a strong marker for bone growth, inflammation and certain cancers. The newly exposed SVVYG epitope on the N-terminal fragment has also been shown to participate in cell adhesion.

Immunogen Sequence:DSVVYG peptide conjμgated to KLH

Target Alternative Name:OPN, BNSP, Bone sialoprotein 1, Nephropontin, Secreted phosphoprotein 1, SPP-1, Urinary stone protein, Uropontin.

Species Reactivities:Recognizes native human OPN from purified breast milk. Specific for the MMP cleavage site DSVVYG of human OPN.

Tag Line:Anti-Osteopontin Monoclonal (Clone 14C08) Antibody

Formulation:1 mg/ml in 0.15 M PBS

Purification: Protein A chromatography from in vitro production

Application:ELISA - Sandwich and Indirect. Pairs well with Cat # 5422-100.

Positive Control:Native Human OPN

Application And Usages:N/A

Handling:The antibody solution should be gently mixed before use.