Anti-NLRP3 Antibody

Anti-NLRP3 Antibodyis available at Gentaur for Next week Delivery.

Description: This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.

Immunogen Sequence:Recombinant protein of human NLRP3

Target Alternative Name:AII/AVP, FCAS, PYPAF1, NLRP3, MWS, NACHT, CIAS1, AGTAVPRL

Species Reactivities:Human

Tag Line:Polyclonal antibody to detect NLRP3 in human samples.

Formulation:PBS with 0.05% sodium azide, 50% glycerol, PH7.3

Purification: Affinity purification

Application:Immunohistochemistry (IHC)

Positive Control:/

Application And Usages:IHC 1:15-1:50

Handling:The antibody solution should be gently mixed before use.