Anti-NGFR Antibody

Anti-NGFR Antibodyis available at Gentaur for Next week Delivery.

Description: The p75 neurotrophin receptor (p75NTR), a member of the TNF receptor superfamily, is distinguished by multiple cysteine-rich ligand-binding domains, a single transmembrane sequence and a noncatalytic cytoplasmic domain. p75NTR displays paradoxical functions when acting alone or with other receptor proteins. Working in concert with Trk receptors, p75NTR recognizes neurotrophins and transmits trophic signals into the cell. Both p75NTR and TrkA are required to activate PI3K-Akt signaling, while TrkA can individually activate the MAP kinase pathway. In contrast, p75NTR, possibly through JNK, ensures appropriate apoptosis of injured neurons and improperly targeted neonatal neurons.The p75NTR protein undergoes sequential cleavage similar to APP and Notch. First, α-secretase removes the p75NTR ectodomain, eliminating ligand-mediated signaling. At this point, the membrane-tethered cleavage product can still fine-tune Trk-mediated trophic actions.

Immunogen Sequence:A synthesized peptide derived from human NGFR

Target Alternative Name:TNFRSF16; Tumor necrosis factor receptor superfamily member 16; Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; NGF receptor; p75 ICD; CD271

Species Reactivities:Human, Mouse, Rat

Tag Line:Polyclonal antibody to detect endogenous levels of NGFR in human, mouse and rat samples

Formulation:In phosphate buffered saline , pH 7.4, 150 mM, NaCl, 0.02% sodium azide and 50% glycerol.

Purification: Affinity purified

Application:WB, IHC, IF

Positive Control:WB: Mouse brain lysate, IF: HepG2 cells, IHC: human glioma tissue

Application And Usages:WB 1:500-1:2000 IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA (peptide) 1:20000-1:40000

Handling:The antibody solution should be gently mixed before use.