Anti-NEUROD2 Antibody

Anti-NEUROD2 Antibodyis available at Gentaur for Next week Delivery.

Description: Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter.

Immunogen Sequence:KLH-conjugated synthetic peptide encompassing a sequence within the center region of human NEUROD2

Target Alternative Name:BHLHA1; NDRF; Neurogenic differentiation factor 2; NeuroD2; Class A basic helix-loop-helix protein 1; bHLHa1; NeuroD-related factor; NDRF

Species Reactivities:Human, Mouse

Tag Line:Polyclonal antibody to detect endogenous levels of NEUROD2 in human and mouse samples

Formulation:In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide

Purification: Affinity purified

Application:WB, IHC, IP

Positive Control:WB: Jurkat; mouse brain; rat brain whole cell lysates, IHC: human brain tissue

Application And Usages:WB; 1:500 – 1:1000, IHC; 1:100 – 1:200, IP; 1:10 – 1:100

Handling:The antibody solution should be gently mixed before use.