Description
Anti-IGF-1R (Teprotumumab), Human IgG1 Antibodyis available at Gentaur for Next week Delivery.
Description: The research-grade biosimilar is a fully human IgG1 monoclonal antibody that binds to the α-subunit domain of IGF-1R. IGF-1R is overexpressed in orbital fibroblasts of patients suffering from thyroid eye disease. Thyroid eye disease is a manifestation of Grave’s disease that is associated with inflammation of orbital muscles and fatty tissues. Although the mechanism of action of the original drug has not yet been fully characterized, binding of the drug to IGF-1R has been reported to internalize and degrade the receptors, and thus inhibit tissue inflammation and remodeling associated with Thyroid eye disease. In 2020, the US FDA approved the application of the drug to treat Graves-associated ophthalmopathy
Immunogen Sequence:Human IGF-1R
Target Alternative Name:RO4858696-000, R-1507, RV-001, IGFR, CD221, IGFIR, JTK13
Species Reactivities:Human
Tag Line:The biosimilar is a human monoclonal antibody that targets human insulin-like growth factor 1 receptor (IGF-1R) signaling and inhibits downstream inflammatory pathophysiology underlying Thyroid Eye Disease (TED)
Formulation:In PBS, pH 7.5
Purification: Protein A purified
Application:/
Positive Control:/
Application And Usages:/
Handling:The antibody solution should be gently mixed before use.
Additional Information
Size: |
100 µg |
Antibody Target: |
IGF-1R |
Category: |
Biosimilars |
Host: |
Recombinant |
Antibody Type: |
Monoclonal |
Isotype: |
IgG1 |
Accession Number: |
DB06343 |
Concentration: |
1 mg/ml |
Appearance: |
Colorless liquid |
Form: |
Liquid |
Storage Condition: |
-80ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
12 months |
Country of Animal Origin: |
USA |
Country of Manufacture: |
USA |
Usage: |
For Research Use Only! Not to be used in humans. |
Western Blot Verified: |
FAUX |
Immunocytochemistry Verified: |
FAUX |
Immunofluorescence Verified: |
FAUX |
Immunoprecipitation Verified: |
FAUX |
FACS Verified: |
FAUX |
ELISA Verified: |
FAUX |
ChIP Verified: |
FAUX |
Dot Blot Verified: |
FAUX |
Flow Cytometry Verified: |
FAUX |