Anti-HDAC6 Monoclonal Antibody (ZnF domain-specific)

Anti-HDAC6 Monoclonal Antibody (ZnF domain-specific)is available at Gentaur for Next week Delivery.

Description: The affinity purified mouse monoclonal antibody is immunospecific for the ZnF domain of human histone deacetylase 6 (HDAC6) as determined by ELISA and peptide library screening. HDAC6 belongs to the class II of the histone deacetylase family (EC 3.5.1.98). The protein of molecular mass 131 kDa consists of two catalytic domains, the serine-glutamate-rich SE14 domain and the ubiquitin-binding ZnF domain. HDAC6 shuttles between the nucleus and the cytoplasm, but its localization is predominantly cytoplasmic. The enzyme deacetylates various substrates including α-tubulin, HSP90, cortactin, histones and other proteins. Described protein plays an important role in microtubule-dependent cell motility, apoptosis, cell signaling and transcriptional regulation, protein degradation, immune response and DNA repair. HDAC6 is linked to several neuronal diseases and carcinogenesis

Immunogen Sequence:Human Histone deacetylase 6 (HDAC6; sequence NP_006035.2, UniProtKB - Q9UBN7)

Target Alternative Name:KIAA0901, JM21, HD6, HDAC6-ZnF

Species Reactivities:Human

Tag Line:Mouse monoclonal antibody to detect HDAC6 (ZnF Domain) in human samples

Formulation:1 mg/ml in PBS, pH 7.4, 0.02% sodium azide

Purification: Affinity purified from hybridoma culture supernatant (Protein A)

Application:ELISA, IC/IF, IP

Positive Control:HEK293T cells

Application And Usages:ELISA: 0.5 – 5µg/ml; Immunocytochemistry/Immunofluorescence: 5 – 50 µg/ml; IP: 1 – 2 µg mAb/1 µg purified HDAC6

Handling:The antibody solution should be gently mixed before use