Anti-cIAP-1 (HIAP-2) Polyclonal Antibody

Anti-cIAP-1 (HIAP-2) Polyclonal Antibodyis available at Gentaur for Next week Delivery.

Description: Apoptosis can be inhibited by a group of proteins called inhibitors of apoptosis (IAPs). These proteins contain a BIR (baculovirus IAP repeat) domain near the amino-terminus. The BIR domain can bind some caspases. Many members of the IAP family of proteins block proteolytic activation of caspase-3 and –7. For example, XIAP, cIAP-1 and cIAP-2 appear to block cytochrome c-induced activation of caspase-9, thereby preventing initiation of the caspase cascade. Since cIAP-1 and cIAP-2 were first identified as components in the cytosolic death domain-induced complex associated with the TNF family of receptors, they may inhibit apoptosis by additional mechanisms.

Immunogen Sequence:Synthetic peptide surrounding amino acid 530 of human cIAP-1

Target Alternative Name:API1 , cIAP1, C-IAP1 , HIAP-2 , HIAP2 , RNF48 , MIHB, IAP2, BIRC2

Species Reactivities:Tested in Human

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Formulation:0.5 mg/ml affinity purified rabbit polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.5 mM EDTA and 0.03% Proclin

Purification: Affinity purified

Application:Western blot

Positive Control:Western Blot: Jurkat cell lysate. IHC: Kidney tissue

Application And Usages:The antibody can be used for Western blot analysis (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Jurkat cell lysate can be used as positive controls.

Handling:The antibody solution should be gently mixed before use.