Anti-CD34 Rabbit Monoclonal Antibody

Anti-CD34 Rabbit Monoclonal Antibodyis available at Gentaur for Next week Delivery.

Description: This mAb recognizes a single chain, transmembrane, heavily glycosylated protein of 90-120kDa, which is identified as CD34. On the basis of differential sensitivity to degradation by specific enzymes, epitopes of monoclonal antibodies to CD34 are classified into a three main categories, class I, class II and class III. It is a class II antibody whose epitope is resistant to neuraminidase but sensitive to glycoprotease and chymopapain. CD34 expression is a hallmark for identifying pluripotent hematopoietic stem or progenitor cells. Its expression is gradually lost as lineage committed progenitors differentiate. CD34 is a marker of choice for staining blasts in acute myeloid leukemia. In addition, CD34 is expressed by soft tissue tumors, such as solitary fibrous tumor and gastrointestinal stromal tumor. Its expression is also found in vascular endothelium. Additionally, it appears that proliferating endothelial cells express this molecule more than the non-proliferating endothelial cells. Anti-CD34 labels > 85% of angiosarcoma and Kaposi’s sarcoma, but with a lower specificity.

Immunogen Sequence:A peptide corresponding to the C-terminus of human CD34

Target Alternative Name:CD34; Hematopoietic progenitor cell antigen CD34, Hematopoietic Progenitor Cell Antigen, HPCA1, Mucosialin

Species Reactivities:Human

Tag Line:Monoclonal antibody to detect CD34 in human samples.

Formulation:In 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide

Purification: Affinity purified

Application:WB, IHC

Positive Control:WB: mouse spleen tissue lysate, IHC: human kidney tissue section

Application And Usages:WB: 1:100-1:200, IHC: 1:100-1:200

Handling:The antibody solution should be gently mixed before use.