Anti- CD31 (PECAM-1) Rabbit Monoclonal Antibody

Anti- CD31 (PECAM-1) Rabbit Monoclonal Antibodyis available at Gentaur for Next week Delivery.

Description: Induces susceptibility to atherosclerosis. Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).

Immunogen Sequence:A peptide corresponding to the cytoplasmic domain of human CD31

Target Alternative Name:EndoCAM, GPIIA', PECA1, CD_antigen: CD31, PECAM-1

Species Reactivities:Human

Tag Line:Rabbit monoclonal antibody to detect CD31 in human samples.

Formulation:In 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide

Purification: Affinity purified using protein A

Application:IHC, WB

Positive Control:WB: Jurkat cell lysates; IHC: human breast cancer tissue

Application And Usages:IHC: 1:1000 -1:2500 dilution; WB: 1:1000 - 1:2000 dilution

Handling:The antibody solution should be gently mixed before use.