Anti-alpha 5 beta 1 Integrin (Volociximab), Human IgG4 Antibody

Anti-alpha 5 beta 1 Integrin (Volociximab), Human IgG4 Antibodyis available at Gentaur for Next week Delivery.

Description: The antibody binds specifically to a5ß1 integrin, which is part of the superfamily of glycoprotein transmembrane receptors for ligands such as fibronectin, vitronectin, laminins and collagens. The a5ß1 integrin receptor plays a key role in cellular processes such as inflammation, cell proliferation, angiogenesis and tumour metastasis. Comprising the variable domain of the original mouse antibody, a chimeric mouse:human IgG4 version of this antibody has been tested in vivo: In cynomolgus monkeys with laser-induced choroidal neovascularization (CNV), in rabbit models and in human volunteers. The antibody reached Phase II clinical trials with PDL Biopharma and Biogen-Idec.

Immunogen Sequence:Heterodimeric α5β1Fc fusion protein

Target Alternative Name:Fibronectin receptor; CD49 antigen-like family member E; Integrin alpha-F; VLA-5; CD49e

Species Reactivities:Human

Tag Line:Monoclonal antibody to detect alpha 5 beta 1 Integrin in human samples.

Formulation:200 µg affinity purified human antibody in phosphate-buffered saline (PBS) containing 0.02% Proclin 300

Purification: Affinity purified using protein A

Application:ELISA; FC; IF; Block; IHC

Positive Control:N/A

Application And Usages:/

Handling:The antibody solution should be gently mixed before use