Anti-Alkaline Phosphatase Antibody (ALPL/597)

Anti-Alkaline Phosphatase Antibody (ALPL/597)is available at Gentaur for Next week Delivery.

Description: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypo-phosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

Immunogen Sequence:Recombinant human ALPL protein

Target Alternative Name:Alkaline phosphatase, germ cell; Alkaline phosphatase, testicular and thymus, Alkaline phosphatase liver/bone/kidney, Alkaline phosphatase, tissue-nonspecific, ALPG, ALPL, Germ cell alkaline phosphatase, Testicular and thymus alkaline phosphatase, Tissue non-specific alkaline phosphatase, Tissue nonspecific ALP (TNAP or TNSALP)

Species Reactivities:Human

Tag Line:Monoclonal antibody to detect Alkaline Phosphatase in human samples

Formulation:In 10 mM PBS with 0.05% BSA & 0.05% azide

Purification: Protein A/G purification

Application:FC, IF, IHC

Positive Control:IHC: human endometrial carcinoma, human testicular carcinoma, human ovarian carcinoma, human colon carcinoma

Application And Usages:FC: 0.5-1 ug/1X106 cells in 0.1 ml, IF: 0.5-1 ug/ml, IHC: 1:50-1:100

Handling:The antibody solution should be gently mixed before use.